I'm really excited for Red Dead Redemption. It's basically GTA in the wild west. Rockstar has come out and done live demos of it twice, and both times it's looked great. I'm a fan of westerns though, so I'm a bit biased.
If you pre-order it from Amazon you'll get a $10 gift card once it releases.
I have a big backlog of games, and almost never buy anything right when it releases, but I'm really tempted to make an exception for this one.